CD 4 1 CD 25 high Regulatory Cells in Human Peripheral Blood 1

CD 4 1 CD 25 high Regulatory Cells

بررسی تعداد سلول‌های T تنظیمی در بیماران مبتلا به بیماری کرون

Background and purpose: Crohn disease (CD) is an autoimmune disorder in which a failure of tolerance to the intestinal antigens plays a pivotal role in the pathogenesis of this disease. Treg cells control immune responses to self and foreign antigens and have an important role in maintaining self-tolerance. In this study we evaluated the frequency of Tregs in the peripheral blood of patients wi...

Distribution of CD 4 + CD 25 + T cells and graft - versus - host disease in human hematopoietic stem cell transplantation

CD25 + T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD). Methods : Seventeen children who underwent HSCT were investigated. CD4 + CD25 + T cells in samples from donor grafts and recipient peripheral blood were assessed by flow cytometry at 1 and 3 months after transplantation. Results : CD4 + CD25 + T cell fre...

Nonregulatory ) T Cells − CD 25 + ( Regulatory ) versus CD 4 + CD 25 + CD 4 Platelet Factor 4 Differentially Modulates

Expression of TIM-3, Human β-defensin-2, and FOXP3 and Correlation with Disease Activity in Pediatric Crohn’s Disease with Infliximab Therapy

BACKGROUND/AIMS This study investigated the expression of T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3), human β-defensin (HBD)-2, forkhead box protein 3 (FOXP3), and the frequency of CD4(+) CD25(+) FOXP3(+) regulatory T cells (Tregs) in children with Crohn's disease (CD) during infliximab therapy. METHODS We enrolled 20 CD patients who received infliximab treatment fo...